From Exercise to Cognitive Performance: Role of Irisin

The beneficial effects of exercise on the brain are well known. In general, offers an effective way to improve cognitive function in all ages, particularly elderly, who considered most vulnerable neurodegenerative disorders. this regard, myokines, hormones secreted by muscle response exercise, have recently gained attention as mediators. Irisin is a novel exercise-induced myokine, that modulates several bodily processes, such glucose homeostasis, and reduces systemic inflammation. cleaved from fibronectin type III domain containing 5 (FNDC5), transmembrane precursor protein expressed under control peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α). FNDC5/irisin system also hippocampus, where it stimulates expression neurotrophin brain-derived neurotrophic factor area associated with learning memory. review, we aimed discuss role irisin key mediator synaptic plasticity memory suggesting its roles within main promoters brain.